Unusual sugar from cyanobacteria acts as natural herbicide
Feb. 4, 2019
Chemists and microbiologists at the University of Tübingen discovered an unusual antimetabolite with a simple chemical structure: a sugar molecule with the scientific name 7-deoxy-sedoheptulose (7dSh). Unlike ordinary carbohydrates, which usually serve as an energy source for growth, this substance inhibits the growth of plants and microorganisms, such as bacteria and yeasts. The sugar molecule blocks a key enzyme of the shikimate pathway, a metabolic pathway that occurs only in microorganisms and plants. For this reason, the scientists classify the substance as harmless for humans and animals, and have already demonstrated this in initial studies.
The rare deoxy sugar was isolated from cultures of the freshwater cyanobacterium Synechococcus elongatus, which is able to inhibit the growth of related bacterial strains. While searching for the cause of this growth inhibition, scientists deciphered the structure of the natural compound. Through a newly developed method for the production of 7dSh – a chemoenzymatic synthesis – the scientists were able to conduct extensive studies to determine the molecular mechanism of 7dSh.
The scientists used coupled high-resolution mass spectrometry to obtain precise insights into the inhibition mechanism and discovered that 7dSh blocks Dehydroquinatesynthase (DHQS), an enzyme of the shikimate pathway. One of the best-known inhibitors of this metabolic pathway to date is the controversial herbicide glyphosate. "In contrast to glyphosate, the newly discovered deoxy sugar is an entirely natural product that is believed to have good degradability and low ecotoxicity," says Dr. Klaus Brilisauer. So far, 7dSh inhibits plant growth promisingly. "We see an excellent opportunity here to use it as a natural herbicide."
Scientists hope to replace controversial herbicides in the long term and thus reduce herbicide metabolites, which pose a health risk. However, effectiveness in the field, degradability in the soil and harmlessness to livestock and humans would have to be further investigated in comprehensive long-term studies for 7dSh.
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