Novel agro anti-biotic – doramectin passed acceptance in China

Recently the Doramectin Metabolic Engineering Program carried out by China Northeast Agricultural University passed the completion acceptance inspection. The Program aims to configure the doramectin metabolic engineering,through which research is made on processing of formulations for applications in agro-field.

Doramectin is a new-generation macrolide antiparasitics developed in the 90’s last century, being regarded as one of the best antiparasitic agents of avermectin derivatives and is effective both internally and externally against nematode and arthropod. Doramectin has good features in respect of toxicity, safety, stability and inoxidizability; its application to agro-field presents a significant effect on prevention and control of acarid and arthropod. As a third-generation agro antibiotic, doramectin is especially effective against plutella xylostella and cotton bollworm which can cause serious damages to crops.

Moreover doramectin does not produce cross-resistance to the commonly used pesticide, and has a low toxicity toward non-targeted organism, being very safe for human and other mammals as there are no significant residues to be left over in farm product; doramectin can be used as a replacement for high-toxic and high-residue chemical pesticide to facilitate production of pollution-free and residue-free green farm product.

The Doramectin Metabolic Engineering Program uses its own streptomyces avermitilisNEAU1069 as original bacterial strain to acquire high-quality engineering bacteria for metabolization of doramectin via genetic engineering technology, being identified as a novel streptomyces avermitilis, which is of proprietary intellectual property rights.

The engineering bacteria enablethe per-unit yield to be maintained at 1150μg/ml on a 70T fermentator production line, 150 times higher than wild bacteria strain-based yield,therefore the per-unit yield is relatively higher and is more applicable to industrialized production of doramectin.