Lansheng Biotech: Enhancing process engineering to increase isoxadifen-ethyl production capacity

The environmental impact assessment for the 1,500t/a isoxadifen-ethyl expansion project of Hebei Lanrun Plant Protection Technology Co., Ltd., a wholly-owned subsidiary of Hebei Lansheng Biotech Co., Ltd. (Lansheng Biotech), was publicly released on relevant websites recently. 

As disclosed by Lansheng Biotech to AgroPages, the company has made substantial progress over the years, establishing isoxadifen-ethyl as one of its competitive products. Lanrun Plant Protection leads its domestic peers in terms of production technology and certifications for isoxadifen-ethyl. At the same time, Lansheng Biotech holds legal export authorization for the compound, ensuring compliance and legality for both domestic and international customers. Furthermore, Lansheng Biotech possesses GLP documentation that supports registration in European and American markets, facilitating collaborative market expansion with clients.

Sample Isoxadifen of Lansheng Biotech

Isoxadifen-ethyl: Improving the safety and application range of herbicides

Isoxadifen-ethyl acts as a broad-spectrum safener, primarily reducing or eliminating the phytotoxicity of sulfonylurea herbicides on crops. It enhances selectivity for corn by limiting the translocation of parent sulfonylurea compounds. This mechanism of action not only decreases the translocation of isoxadifen-ethyl but also speeds up detoxification metabolism, thereby mitigating the phytotoxicity of herbicides. As a result, it effectively reduces the inhibition of corn plant height and fresh weight by herbicides, improves crop tolerance, addresses issues with resistant weeds, and broadens the application range of herbicides.

In the last two years following the expiration of the tembotrione patent, this compound has quickly gained popularity in China’s herbicide market. As a safety companion for tembotrione in cornfields, isoxadifen-ethyl has attracted significant attention from the industry. It is primarily used in herbicides for corn, rice, and other grass crops, often in combination with products such as nicosulfuron, tembotrione, rimsulfuron, foramsulfuron, and fenoxaprop-p-ethyl. Major multinationals such as Bayer and DuPont have developed a range of herbicides utilizing isoxadifen-ethyl as the safener, with carefully formulated ratios to maximize efficacy—such as a 1:4 ratio with nicosulfuron, 1:2 with rimsulfuron, 1:1 with foramsulfuron, and 1:2 with tembotrione.

Herbicides play a vital role in agricultural cultivation. While foreign companies have seen a slowdown in the research and development of new herbicides, the study and application of safeners continue to advance and evolve. Safeners not only extend the lifespan of older herbicide varieties but also open up new application opportunities for existing products, driving ongoing advancements in research and application in this field.

Lansheng Biotech: Decade of Commitment to Excellence in Safener Development

Lansheng Biotech has been dedicated to the research and production of safeners since 2015, with isoxadifen-ethyl being its flagship product. Currently, its wholly-owned subsidiary, Hebei Lanrun Plant Protection Technology Co., Ltd., has established an automated production line with an annual capacity of 1,500 tons of isoxadifen-ethyl and plans to put it in operation soon.

The company operates under the philosophy of ″Quality First, Excellence Foremost,″ implementing a comprehensive quality management system that aligns with its vision and market positioning while setting benchmarks against the quality of innovator products. Lansheng Biotech enforces strict management practices at every stage—from incoming raw material to production process control and final product delivery—ensuring rigorous quality control throughout the entire process. This dedication not only enhances product quality but also gradually meets and even exceeds the quality of innovator products, giving the company a competitive edge in the market. Furthermore, the company has established a vital customer service and after-sales support system. By gathering customer feedback, Lansheng continuously enhances product quality and service standards, thereby improving customer satisfaction and experience. This approach ensures that its quality strategies and objectives consistently align with market demands.

Technological innovation is a relentless pursuit for Lansheng Biotech. The company has made significant strides in production scale and efficiency by continuously optimizing its fully automated isoxadifen-ethyl production process. With the shift to large-scale manufacturing, Lansheng has gained a competitive edge in cost control for isoxadifen-ethyl, further enhancing the market competitiveness of the product.

Building on China’s comprehensive industrial system, healthy and stable social environment, and extensive international cooperation network, Lansheng Biotech remains customer-centric. The company profoundly understands and accurately addresses the specific needs of different clients, employing flexible and diverse strategies to tailor collaboration plans. This approach ensures that partners can receive maximum value from their cooperation and achieve a win-win situation.

Looking ahead, Lansheng Biotech anticipates establishing solid and mutually beneficial long-term partnerships with more industry players to advance the development and innovation of global agricultural technology collaboratively. The company is committed to delivering green, efficient, and environmentally friendly solutions for agricultural production, enhancing crop yields and quality while contributing to sustainable development goals.