Australia to approve Syngenta’s Simodis Plinazolin Technology Insecticide (isocycloseram 100 g/L DC)

The Australian Pesticides and Veterinary Medicines Authority (APVMA) is considering an application for registration of Syngenta Australia Pty Ltd.’s new product Simodis Plinazolin Technology Insecticide, containing 100 g/L, as dispersable concentrate of the active constituent isocycloseram.

Isocycloseram is a member of the isoxazoline chemical family and belongs to a new IRAC Mode of Action Group 30 (IRAC 2021). It acts at the gamma-aminobutyric acid (GABA) receptor as an antagonist with a novel mode of action.

The compound works on all insect and mite stages, via contact and/or ingestion. Symptoms include paralysis and inactivity. As the compound is metabolised very slowly in the target pest, and the mechanism of action is also slow, pests will assimilate doses beyond the toxic dose before symptoms set in, making the product a very effective insecticide/miticide against crop pests. To date, no cross-resistance to other modes of action has been identified.

Isocycloseram was approved in 2021 (approval number 89440) as a new active constituent. However, there are no products containing isocycloseram currently registered.

This proposed product, Simodis Plinazolin Technology Insecticide, is intended for the control of certain insect and mite pests in vegetables.

The APVMA Chemistry section has evaluated the chemistry of the isocycloseram active constituent and the associated product Simodis Plinazolin Technology Insecticide including the physicochemical properties, identification, manufacturing process, quality control procedures, stability data, batch analysis results and analytical methods, and found them to be acceptable.

Based on a review of the chemistry and manufacturing details, the registration of Simodis Plinazolin Technology Insecticide and approval of the isocycloseram active constituent, are supported from a chemistry perspective.