CORRECTION: ISO approves common name of KingAgroot’s herbicide Broclozone and GreenLight Biosciences’ RNA Biopesticide Ledprona

In the previous version of this news article, FMC Corporation was incorrectly referred to. Broclozone is a patented product of KingAgroot, not FMC Corporation. This declaration is hereby issued as an apology. 

ISO approves common name of KingAgroot’s herbicide Broclozone and GreenLight Biosciences’ RNA Biopesticide Ledprona.

Broclozone

Broclozone (development code code KAI-172402, Chinese common name 溴噁草松), a patented pesticide of KingAgroot, is a new herbicide belonging to the isoxazolidinone chemical class. Broclozone is the newest DOXP-inhibiting herbicide with both foliar and soil activity, is suitable for many crops such as wheat, rice, soybean, cotton, garlic, peanut, watermelon, oilseed rape, cabbage and various crops, and has selectivity for a wide range of crops and flexibility in subsequent crop planting. According to KingAgroot, Broclozone is expected to be registered and launched in China around 2025.

• STATUS: ISO 1750 (Provisionally Approved)

• IUPAC Name: 2-(2-bromo-4-chlorobenzyl)-4,4-dimethylisoxazolidin-3-one

• CAS Name: 2-[(2-bromo-4-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone

• CAS RN.: 2766607-82-1

• Molecular Formula: C₁₂H₁₃BrClNO₂

• Activity / Indication: Herbicides (isoxazolidinone)

• INCHIKEY: QYTLRSSSVHIPGB-UHFFFAOYSA-N

• INCHI: InChI=1S/C12H13BrClNO2/c1-12(2)7-17-15(11(12)16)6-8-3-4-9(14)5-10(8)13/h3-5H,6-7H2,1-2H3  
  

Ledprona

Ledprona is developed by GreenLight Biosciences, USA. Ledprona is a sprayable double-stranded RNA biopesticide, assigned CAS RN. 2766607-82-1 with a new mode of action that triggers the RNA interference pathway. Ledprona, currently pending registration at EPA, represents a new biopesticide class integrated pest management and insecticide resistance management programs directed against CPB.

Ledprona, the active ingredient in GreenLight’s Calantha™ product, is approved as a new mode of action in the recent winter meeting of IRAC, an international association of crop-protection companies that focuses on resistance management and sustainable agriculture.

The first foliar-applied, dsRNA-based bioinsecticide that provides effective control of CPB, Calantha™ is expected to be registered in the United States this year. The Colorado potato beetle (Leptinotarsa decemlineata) ravages plants like potatoes and eggplant and accounts for more than $500 million in annual crop loss worldwide.

For decades, insect resistance to pesticides has challenged growers. Using integrated pest management, which includes rotating insecticides, farmers and agronomists can prolong the useful lifespan of crop treatments. GreenLight’s product is designed to work well with standard growers’ programs to control first- and second-generation Colorado potato beetle infestations.

Calantha™ has a unique mode of action among chemical and biological insecticides, which will provide farmers with a new tool aimed at protecting potato and eggplant fields from the Colorado potato beetle and supporting their efforts at resistance management.

Ledprona, expected to be classified as IRAC MoA group 35 (RNAi-mediated targeted suppressors), specifically targets only CPB, causing the beetle to stop eating and expire from the accumulation of its own metabolic waste. Because it is based on double-stranded ribonucleic acid, Calantha™ degrades quickly in the environment, supports biodiversity, and is an example of the next generation of eco-friendly crop-protection products.

The Insecticide Resistance Action Committee helps growers around the world by developing mode-of-action classification schemes; identifying new technologies for insect, mite, and tick control products; and implementing insecticide resistance management strategies for crop protection, plant biotechnology, and public health.