Australia to approve Bayer's Xivana Prime 20 SC Fungicide containing fluoxapiprolin

The Australian Pesticides and Veterinary Medicines Authority (APVMA) has proposed to approve Bayer CropScience Pty Ltd’s Xivana Prime 20 SC Fungicide, containing 20 g/L of the new active constituent fluoxapiprolin in a suspension concentrate formulation.

Fluoxapiprolin is a novel fungicide from the piperidinyl thiazole isoxazoline chemical class. It belongs to the oxysterol binding protein inhibitor mode of action and is active against a wide range of oomycete fungi.

Xivana Prime 20 SC Fungicide is to be applied at 37.5 to 50 mL/100 L in grapevines for the control of downy mildew (Plasmopara viticola). No more than 2 applications of Xivana Prime 20 SC Fungicide may be applied to grapevines per growing season with the last application no later than pre-bunch closure.

The APVMA Chemistry section has evaluated the chemistry of the active constituent fluoxapiprolin and associated product Xivana Prime 20 SC Fungicide, including the identification, physicochemical properties, manufacturing process, quality control procedures, stability, batch analysis results and analytical methods and found them to be acceptable. Based on a review of the chemistry and manufacturing details, the registration of Xivana Prime 20 SC Fungicide, and approval of the active constituent fluoxapiprolin, are supported from a chemistry perspective.

The APVMA invites comment from 5 April 2022 to 3 May 2022 on whether approval of the active constituent and registration of the product should be granted.