Harnessing the power of CRISPR to reduce poverty and malnutrition

A five-year partnership being launched by the Innovative Genomics Institute (IGI) — a non-profit founded by Nobel Laureate Jennifer Doudna — and CGIAR, the world’s largest publicly-funded agricultural research partnership, will harness the power of science to help millions of people overcome poverty, hunger, and malnutrition.

One in four people globally, and rising, are unable to afford a healthy diet. COVID-19 has exacerbated this trend by disrupting food production and distribution, driving up by 20 percent the number of people threatened by hunger in 2020. The pandemic is unfolding amidst an environmental and climate crisis which is undermining food production and our ability to nourish the world.

According to Barbara Wells, Global Director for Genetic Innovation at CGIAR: “World-class science is vital for facilitating farmer adaptation and mitigating our food system’s contribution to climate change. Plant-breeding innovations can help ramp up food production while making farms more climate resilient, profitable, and environmentally friendly”.

“Technologies such as gene editing, which enable scientists to make targeted changes to a crop’s DNA, can accelerate the development of more disease-resistant, water-efficient varieties that can improve food production and nutrition in areas that are especially vulnerable to climate change,” Dr. Wells explained.

CGIAR has produced and promoted innovations that are boosting the sustainable production of nutritious food in Africa, Asia and Latin America. Over the past five decades, CGIAR scientists and national partners have developed and disseminated robust and highly productive crop varieties and livestock breeds tailored to the needs of local men and women. Those innovations have helped hundreds of millions of people across the Global South overcome hunger and poverty.

The IGI is a collaboration of the University of California, Berkeley and the University of California, San Francisco with a mission to develop revolutionary genome-editing tools that enable affordable and accessible solutions in human health, climate, and agriculture. The IGI’s Climate & Sustainable Agriculture program focuses on developing crops that are resistant to pests and diseases, resilient to a changing climate, and less dependent on farmer inputs. Whereas the IGI is a pioneer in applied genomic research, CGIAR focuses on translating discoveries into improved crop varieties and cropping systems. This partnership provides an accelerated pipeline from upstream innovation to real-world impact.  

“The IGI is testing technologies with great potential to benefit people in the countries where CGIAR is active, such as a way of removing the cyanide found in cassava—a staple upon which nearly a billion people depend — and fighting diseases in economically important crops like wheat, rice, and bananas,” said Dr. Brian Staskawicz, the IGI Director of Sustainable Agriculture.

“The IGI is also pioneering new ways to reduce methane emissions from rice farming, which accounts for 2.5 percent of humanity’s contribution to global warming, by using genomic approaches to reduce methane production by soil microbes,” he added.

“By partnering with CGIAR, the IGI can ensure that the products of its research will benefit farmers and consumers in some of the world’s poorest countries, where CGIAR has been working for 50 years and has extensive partner networks,” said Dr. Melinda Kliegman, Director of Public Impact at the IGI. “Together we can accelerate the development and delivery of more climate-resilient, productive and nutritious crops for resource-poor farmers and consumers.”

Over the next five years, the IGI and CGIAR will use the latest breakthroughs in genomic science to enhance the resilience and productivity of farmers in low- and middle-income countries and improve the wellbeing and livelihoods of women and men in some of the world’s poorest communities.

Photo: Researchers at work at CGIAR’s International Institute of Tropical Agriculture campus in Ibadan, Nigeria (Chris de Bode/CGIAR)