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Pesticides Registered & Launched in 2017 and Analysis of Key Productsqrcode

Apr. 5, 2018

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郑敏 Paul Zheng
Paul Zheng

Paul Zheng, editor of AgroPages.com. Email: paul@agropages.com

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Nowadays it takes roughly 11 years beginning from research and development of a novel active ingredient up to release of pesticide to market, at a cost of $286 million, which is 55 percent higher versus 10 years ago. Research and development of novel active ingredients are getting more difficult, which is well recognized among the industry beyond dispute. In 2017, all prime agrochemical enterprises have registered or launched a number of novel pesticide products in the world. However an awkward situation is that there have been few registrations or launches of novel active ingredients of pesticide in 2017. This article makes a summary of pesticides newly registered or launched in 2017 while giving highlight on the several novel active ingredients registered or launched in the year.
 
Tioxazafen
 
On the 1st May 2017, registration of Monsanto’s seed treatment nematicide NemaStrikeTM was approved by the U.S. EPA, having become an integral part of Monsanto’s Acceleron® Seed Applied Solutions. As known to all, compared with Syngenta, DowDupont and Bayer CropScience, Monsanto has not made big moves concerning novel pesticide development. In early 2017, Monsanto announced more than 20 research achievements over 4 consecutive years, where 14 products are about to be commercialized, which have included tioxazafen, the active ingredient of NemaStrike.  
 
Tioxazafen is a broad-spectrum and systemic seed treatment nematicide developed by Monsanto in 2013, being a di-substituted oxadiazole. The new structure gives tioxazafen a new action mechanism, where the difference from other nematicides available on the market is that tioxazafen acts via interference with nematode ribosome. Hence, there is no cross resistance to other nematicides.  
 
Tioxazafen is presently registered for application on corn, soybean and cotton for control of plant pathogenic nematode, such as cyst nematode, root-knot nematode, reniform nematode, root lesion nematode and longidorus. It’s application to vegetable is still under the way. Over the last 3 years Monsanto has conducted large amount of tioxazafen-oriented field trial and green house experiments, the results show that the control effect of tioxazafen as applied to various crops is equivalent or superior to the already commercialized products. Furthermore, it increases yield of corn, soybean and cotton.
 
The excellent control effect of tioxazafen originates from its distinctive control function, which is different from the inhibiting function of other nematicides. Nematode has a life cycle of about 30 days, tioxazafen SC has a low water solubility and can remain at around plant root system for a prolonged period, thus to provide a 75-day long lasting effect, which is 2.5 times of the life cycle of nematode.
 
It is worthy of note that tioxazafen is on;y registered for use in a production facility with full-automatic seed treatment equipment, where sealed conveyor and application device are used. Its use for on-site seed treatment is prohibited. 
 
In September 2017, Monsanto announced release of NemaStrike to Brazilian market. As a novel active ingredient, tioxazafen enjoys 10-year registration protection rights, to be valid until 30th April 2027.
 
Florpyrauxifen
 
On the 31st August 2017, Dow AgroSciences obtained registration with China’s ICAMA of its herbicide florpyrauxifen 91.4% TC and florpyrauxifen 3% EC (trade name Rinskor®), this is the world’s first-time registration of florpyrauxifen. On the 15th September 2017, the florpyrauxifen-containing herbicide Loyant of Dow AgroSciences was also approved in U.S..
 
Florpyrauxifen is a novel aryl picolinate herbicide developed by Dow AgroSciences most recently and is a patent product of Dow AgroSciences, it is the second aryl picolinate herbicide following the halauxifen-methyl Arylex™. The trade names of the product include Rinskor® and Loyant®. Florpyrauxifen and halauxifen-methyl are both synthetic auxin herbicide with same action mechanism, acting via interference with the physiological and biochemical function of plant through in vivo hormone receptor binding, thus to cause the death of sensitive plant. However, a difference exists on the molecular structure of the two products, their target and herbicidal activity are different. Florpyrauxifen is mainly used for control of annual weed in rice field while halauxifen-methyl is mainly used for control of broad-leaf weed in grain crop field.
 
Florpyrauxifen has the advantages of broad spectrum, high efficiency, fast action and lower dosage, it can be applied to direct seeding rice, transplanted rice and the rest of crop field for post-emergence foliar treatment and for control of grassy weed, broad-leaf weed and nutgrass flatsedge. Because of its distinctive action mechanism, it can be used for weed resistance management for control of weeds resistant to ALS, ACCase, HPPD inhibitors, propanil, quinclorac, glyphosate and triazine herbicides. Moreover, the product is active on resistant barnyard grass in rice field due to its stable herbicidal property even under different conditions and water situations. Florpyrauxifen has a unique selectivity, which can be used safely to paddy rice and other crop fields.
 
According to Dow AgroSciences, the annual sales of florpyrauxifen is expected to reach over $200 million and total sales are likely to reach $2 billion. In 2017, there have been a lot of publicity and advertising on the florpyrauxifen-based herbicide Rinskor, which is expected to be launched to Chinese market in 2018 and to become an important substitute for penoxsulam.
 
Pydiflumetofen
 
In November 2017, Syngenta released to Argentina its fungicide MIRAVIS® Duo containing Syngenta’s latest active ingredient pydiflumetofen, which is the first-time release in the world. 
 
Pydiflumetofen (trade name Adepidyn) is Syngenta’s latest pyrazole-carboxamide fungicide, it is a most recent SDHI fungicide masterpiece of Syngenta following its releases of Isopyrazam in 2010, sedaxane in 2011 and benzoenoxazole in 2012. Under the circumstance of global agrochemical downturn over recent years, SDHI fungicides have increased 15 percent on a yearly basis, becoming a dark horse in agrochemical market.
 
Being the first new member of chemical group of anthranilic diamides, the release of pydiflumetofen stands for Syngenta’s latest innovation in disease control. Pydiflumetofen is registered mainly for application to small grain crops, corn, soybean and special vegetable for control of gray mold, brown spot and stalk break. According to Syngenta, among the chemical group, pydiflumetofen has the highest activity on leaf spot disease and powdery mildew. It has also been a breakthrough in control of fusarium-caused disease on grain crops, such as fusarium head blight.
 
In November 2016, registration of Syngenta’s MIRAVIS® Duo was approved in Argentina. Syngenta has filed an application for registration of pydiflumetofen in the US, which is currently under review and expected to be approved in 2018. The sales of the product in the US will be in the trade name Miravis™. Syngenta predicts an annual sales of pydiflumetofen to reach a peak value of $750 million, which will become a SDHI fungicide with the highest market potential. 
 
Picarbutrazox
 
In November 2017, Nippon Soda obtained approval in Japan of registration of its two fungicides - Nae Fine Flowable and Pisi Rock Flowable, both containing the novel active ingredient picarbutrazox. Nae Fine Flowable is used for control of rice breeding disease and seedling wilt while Pisi Rock Flowable is mainly used for control of vegetable oomycetes disease.
 
Picarbutrazox is a carbamate fungicide invented by Dainippon Ink and Chemicals (acquired by Nippon Soda in April 2004) and developed by Nippon Soda. The product was launched by Nippon Soda in 2013 and a provisional common name was ISO approved in the same year.
 
Due to the brand-new chemical structure, picarbutrazox possesses a brand-new action mechanism without cross resistance to other fungicides, being an excellent rotational-use spraying product. Picarbutrazox is mainly used for control of oomycetes diseases on melon vegetable, grain crop, tomato, potato, lawn, lettuce and leaf vegetable such as disc peronospora, pythium, peronospora and pseudoperonospora diseases. 
 
Picarbutrazox is currently only registered and launched in Japan. According to the recent active ingredient list announced by U.S.EPA intended for registration in 2019, picarbutrazox is expected to be approved on the 17th April 2019 for application to leaf vegetable, melon vegetable, lawn, corn and soybean seed treatment.
 
Besides the above 4 kinds of novel active ingredients, a number of novel biopesticide have been registered or launched in global market in 2017, including the most representational biofungicide Serifel of BASF which is launched to the US market and the biofungicide Stargus of Marrone Bio Innovations as registered in the US. Serifel is BASF’s first patented biofungicide, with active ingredient being bacillus amyloiquefaciens strain MBI 600. The launch of Serifel marks an important step of the chemical giant BASF toward biological pesticide industry. The active ingredient of Stargus is also a kind of bacillus amyloliquefaciens, which is however a new strain discovered by Marrone Bio Innovations, for control of downy mildew, stalk break, botrytis and fruit rot. It is an important strategic product variety of Marrone Bio Innovations.
 
Though development of novel active ingredients are getting more difficult, what is encouraging is that many companies never stop their effort on research and development of novel pesticide. In the years ahead, a number of novel active ingredients are expected to emerge, which will include the grain crop fungicide fenpicoxamid, a latest development of Dow AgroSciences, the SDHI fungicide pyraziflumid of Nihon Nohyaku and the diamide insecticide tetraniliprole of Bayer CropScience. 

Pesticides registered or launched in 2017


Company

Trade name

Active ingredient

Use

Status

Herbicides

Syngenta

Lumax

S-metolachlor+Mesotrione+ Terbuthylazine

Corn

Launched in Spain

Bayer CropScience

Provence Total

Indaziflam +Isoxaflutole

Sugarcane

Registered in Brazil

BASF

Zidua SC

Pyroxasulfone

Corn,soybean and wheat

Launched in USA

Atectra BV

Dicamba

Corn,wheat,sorghum and sugarcane

Launched in Argentina

Dow AgroSciences

Enlist One

2,4-D

Cotton,corn and soybean

Launched in  USA

Enlist Duo

2,4-D + Glyphosate

GM corn and soybean

Registered in Brazil

Loyant

Rinskor

Rice

Registered in USA

Dupont

EverpreX

S-metolachlor

Soybean

Launched in  North America

Destra IS

Rimsulfuron+Mesotrione

Corn

Registered in Canada

Monsanto

Harness MAX

Acetochlor+ Mesotrione

Corn

Registered in USA

Arysta Life Science

EVEREST 3.0

Flucarbazone-sodium

Wheat

Launched in  North America

Nufarm

Grapple

Rimsulfuron

Grape

Launched in USA

Gesaprim 500 CG

Atrazine

Sugarcane,corn and sorghum

Launched in Brazil

FMC

Battle Delta

Flufenacet+Diflufenican

Cereal

Launched in Italy

UPL

Fascinate

Glufosinate

Soybean,corn,cotton and kidney beans

Registered in Brazil

AMVAC

ImpactZ

Topramezone+Atrazine

Corn

Registered in USA

Gowan

Avanza 400 SC

Benzobicylon

Rice

Registered in Columbia

Gowan

Gambit

Halosulfuron+Prosulfuron

Rice

Registered in USA

Summit Agro USA

SHIELDEX  400SC

Tolpyralate

Corn

Registered in USA

Iharabras S/A Indústrias Químicas

TARGA MAX

Quizalofop-p-ethyl

Soybean

Launched in Brazil

Fungicides

Syngenta

MIRAVIS Duo

Pydiflumetofen + Difenoconazole

Peanut

Launched in Argentina

Instrata Elite

Difenoconazole+Fludioxonil

Turf

Launched in UK

Coratop Mametsubu

Pyroquilon

Rice

Launched in Japan

Elatus Era

Benzovindiflupyr+Prothioconazole

Cereal

Registered in Ireland

Aprovia Top

Difenoconazole+Benzovindiflupyr

Potato

Launched in Canada

Revus Top

Mandipropamid+Difenoconazole

Potato

Launched in Argentina

Bayer CropScience

Prosaro XTR

Prothioconazole+Tebuconazole

Cereal

Launched in Canada

Luna Tranquility

Fluopyram+Pyrimethanil

Fruits

Launched in Chile

FOX Xpro

Trifloxystrobin + Prothioconazole

Soybean

Launched in Brazil

Cropton Xpro

Bixafen + Prothioconazole + Trifloxystrobin

Wheat and barley

Launched in Argentina

Exteris Stressgard

Fluopyram+Trifloxystrobin

Turf

Launched in UK

BASF

Pageant TR Intrinsic

Boscalid+Pyraclostrobin

ornamentals

Launched in USA

Futura

Dithianon+Potassium phosphonate

Potato

Registered in France

Vivando

Metrafenone

Mushroom

Launched in UK

Sercadis

Fluxapyroxad

Potato

Launched in France

Enervin Top

Ametoctradin+Thioneb

Grape

Launched in Spain

Vision Plus

Pyrimethanil+Dithianon

Pome fruits

Launched in Spain

Arysta Life Science

Kaligreen

Potassium bicarbonate

Apple

Launched in Brazil

ADAMA

Cronnos

Mancozeb+Picoxystrobin+Tebuconazole

Soybean

Launched in Brazil

Acadia Bio

Tebuconazole+Azoxystrobin

Soybean,wheat and corn

Launched in Argentina

Nippon Soda

Nae Fine Flowable

picarbutrazox

Rice

Registered in Japan

Pisi Rock Flowable

picarbutrazox

Vegetables

Registered in Japan

Valent U.S.A.

Elumin

Ethaboxam

Cucurbits

Registered in USA

PBI-Gordon

Kabuto SC

Isofetamid

Turf

Registered in USA

Iharabras S/A Indústrias Químicas

Fusão EC

Metominostrobin+Tebuconazole

Soybean

Launched in Brazil

Iharabras S/A Indústrias Químicas

Totalit

Chlorothalonil + Benthiavalicarb-isopropyl

Lettuce, potato, tomato, onion and grapes

Launched in Brazil

Stockton

REGEV

Melaleuca alternifolia extract +Difenoconazole

Vegetables and fruits

Registered in Guatemala

Insecticides

Syngenta

Voliam Targo

Abamectin+Chlorantraniliprole

Horticultural crops

Launched in Spain

Force Evo

Tefluthrin

Corn

Registered in USA

Proclaim 50

Emamectin benzoate

Soybean,cotton and beans

Registered in Brazil

Minecto Pro

Cyantraniliprole+Abamectin

Vegetables

Registered in USA

BASF

Nomolt 150

Teflubenzuron

Apples

Launched in Brazil

Dow AgroSciences

Isoclast

Sulfoxaflor

Cereal and potato

Registered in Ireland

Transform

Sulfoxaflor

Macadamia and avocado

Registered in Australia

Spindle

Spinosad

Coffee, apple and grape

Registered in Brazil

Nufarm

Kaiso Sorbie

Lambda-cyhalothrin

Cotton

Registered in Brazil

ADAMA

Cormoran

Novaluron+Acetamiprid

Apple and pear

Launched in USA

UPL

Sperto

Acetamiprid+Bifenthrin

Soybean,corn

and cotton

Launched in Brazil

Strafer MAX

Acetamiprid

Cotton

Launched in USA

Iharabras S/A Indústrias

Privilege

Acetamiprid+Pyriproxyfen

Soybean,kidney beans,cotton and tomato

Launched in Brazil

Eleitto

Acetamiprid+Ethofenprox

Vegetables and fruits

Launched in Brazil

Summit Agro USA

HARVANTA 50SL

CYCLAPRYN

fruiting vegetables, cucurbits, leafy vegetables and brassica vegetables

Registered in USA

CCAB Agro

Diafentiuron CCAB 500 SC

Diafenthiuron

Cotton,kidney beans and tomato

Registered in Brazil

Nematicides

Bayer CropScience

COPeO Prime

 Fluopyram

Cotton

Launched in USA

ADAMA

Nimitz

Fluensulfone

Sweet potatoes, fruiting vegetables and melons

Registered in Japan,South Korea

Rotam

ReTurn XL

Oxamyl

Potato,cotton,tobacco and peanut

Registered in USA

SipcamRotam

ReTurn

Oxamyl

Vegetables and fruits

Launched in USA

Certis Europe

NEMguard DE

Garlic extract

Carrot

Registered in Netherlands

Seed treatments

Syngenta

Clariva Elite Beans

Pasteuria nishizawae PN1+Fluoxazolamine+ Fludioxonil+ Metalaxyl-M+ Thiamethoxam

Soybean

Registered in USA

Fortenza

Cyantraniliprole

CornandCotton

Registered in USA

PLENARIS

Oxathiapiprolin

Sunflower

Launched in USA

Cruiser 600 FS

Thiamethoxam

Cotton,peanut,rice,sugarcane and soybean

Registered in Brazil

Fortenza Duo

Cyantraniliprole+Thiamethoxam

Soybean,corn and cotton

Launched in Brazil

Plenaris

Oxathiapiprolin

Sunflower

Launched in Argentina

Bayer CropScience

Routine FS

Isotianil

Rice

Launched in Japan

Kirappu Seed FS

Ethiprole

Rice

Launched in Japan

Scenic

Fluoxastrobin+Prothioconazole+Tebuconazole

Cereal

Launched in Chile

BASF

Stamina F4 Cereals

Fluxapyroxad+Pyraclostrobin

Cereal

Registered in USA

Arysta Life Science

Signal 300 ES

Cypermethrin

Wheat and barley

Launched in Ireland

RANCONA V 100 PRO

Ipconazole+Carboxin

Soybean

Launched in North America

Nufarm

Maestro FS

Fipronil

Corn,soybean,rice,barley,kidney beans,wheat,peanut and cotton

Launched in Brazil

Saddler 350 SC

Thiodicarb

Corn and soybean

Launched in Brazil

Biopesticides ( will be released tomorrow )

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